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The N1E cell line was established in by T. Amano, E. Richelson, and M. Nirenberg by cloning the C spontaneous mouse neuroblastoma tumor, C Abstract: Melatonin increases neurite formation in N1E‐ cells through microtubule enlargement elicited by calmodulin antagonism and vimentin intermediate filament reorganization caused by protein kinase C (PKC) activation. Microfilament rearrangement is also a necessary process in growth cone formation during neurite outgrowth.

Upper Grand District School Board Victoria Road N. Guelph, ON N1E 6K2 Switchboard: Toll-free: Email: [email protected]. Studies have evidenced the critical neurotrophic role in the development of ARC. To determine such effects on neuron development, N1E neuroblastoma cells were used as an ARC model. Materials and Methods: N1E neuroblastoma cells were treated with leptin [10 nM] for 24, 48 and 72 hrs. Dimethyl sulfoxide (DMSO) % was used as a known.

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